Antidepressant use and cognitive decline in patients with dementia: a national cohort study.

ABSTRACT:

Background

Dementia is associated with psychiatric symptoms but the effects of antidepressants on cognitive function in dementia are understudied. We aimed to investigate the association between antidepressants and cognitive decline in patients with dementia, and the risk of severe dementia, fractures and death, depending on antidepressant class, drug, and dose.

Methods

This is a national cohort study. Patients with dementia registered in the Swedish Registry for Cognitive/Dementia Disorders-SveDem from May 1, 2007, until October 16, 2018, with at least one follow-up after dementia diagnosis, and who were new users of antidepressants, were included. Antidepressant use as a time varying exposure defined during the 6 months leading up to dementia diagnosis or each subsequent f

SUBMITTER: Mo M 

PROVIDER: S-EPMC11854023 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature