Proteogenomic annotation of T6SS components identified in Bacteroides fragilis secretome.

ABSTRACT:

Introduction

Bacteroides fragilis (Bf)'s T6SS locus has been characterized and shown to have functional activity in competition experiments. It has been demonstrated that symbiont nontoxigenic Bf strains have a more effective "weapon" effect on pathogenic Bf, which is realized through the activity of effector-immune (E-I) protein pairs. Intensive study of the T6SS structure has led to an understanding of certain issues related to its functional activity, but the exact regulatory mechanisms of E-I protein pair activity remain unclear. Proteomic annotation of T6SS components and detailed descriptions of all immune-effector pairs are currently available. In this research, we performed detailed proteogenomic analysis and subsequent proteomic annotation of the T6SS components of

SUBMITTER: Zakharzhevskaya NB 

PROVIDER: S-EPMC11854122 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature