Plasma proteomics for cognitive decline and dementia-A Southeast Asian cohort study.

ABSTRACT:

Introduction

The prognostic utility of plasma proteomics for cognitive decline and dementia in a Southeast Asian population characterized by high cerebrovascular disease (CeVD) burden is underexplored.

Methods

We examined this in a Singaporean memory clinic cohort of 528 subjects (n = 300, CeVD; n = 167, incident cognitive decline) followed-up for 4 years.

Results

Of 1441 plasma proteins surveyed, a 12-protein signature significantly predicted cognitive decline (q-value < .05). Sixteen diverse biological processes were implicated in cognitive decline. Ten proteins independently predicted incident dementia (q-value < .05). A unified prediction model combining plasma proteins with clinical risk factors increased the area under the curve for outcome prediction from 0.62

SUBMITTER: Sim MA 

PROVIDER: S-EPMC11854348 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature