Hippocampal vascularization pattern and cerebral blood flow cooperatively modulate hippocampal tolerable amount of Aβ deposition in the occurrence of MCI.

ABSTRACT:

Background

Aβ deposition in the brain does not necessarily lead to cognitive impairment, and that blood supply may have other unexplained regulatory effects on Aβ. Therefore, there appears to be a more complex relationship between blood supply, Aβ deposition, and cognitive impairment that warrants further exploration.

Methods

This cohort study collected four longitudinal follow-up datasets, including a total of 281 subjects, followed for four years. Three-dimensional time-of-flight angiography and pseudo-continuous arterial spin labeling were used to assess hippocampal vascularization pattern (VP) and hippocampal cerebral blood flow (CBF). 11 C-Pittsburgh compound B (PiB)-PET/CT-based spatial measurements were used detect hippocampal PiB uptake as a reflection of hippocampal

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11854383 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature