Development and Characterization of Niaprazine-Loaded Xanthan Gum-Based Gel for Oral Administration.

ABSTRACT: Niaprazine is a sedative-hypnotic drug initially developed as an antihistamine and used for its notable sedative effects, particularly in children. Following its withdrawal from the market by the producer, the drug has been administered as magistral formulations available in syrup form, but there are several important disadvantages to this, including instability, taste issues, lack of controlled release, and the potential for unreliable dosing due to incomplete swallowing. There is also an increased risk of dental caries, as well as the fact that these formulations are not suitable for children who suffer from diabetes. The purpose of the current investigation is to prepare and characterize xanthan gum-based gels for the oral administration of niaprazine. Niaprazine gels appear as transpar

SUBMITTER: Giuliano E 

PROVIDER: S-EPMC11854669 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature