Dental Manifestations in Children Affected by Hypophosphatemic Rickets: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Hypophosphatemic rickets (HR) is a bone disorder affecting phosphate-calcium metabolism, with both skeletal and dental manifestations. This review aims to analyze dental manifestations of HR in children and, where possible, compare them to those in healthy children or affected adults.

Methods

The protocol was registered at PROSPERO (CRD42024596022). The study conformed to the PRISMA guidelines. Three databases were searched for studies reporting the prevalence or incidence of any dental manifestation in children with HR. Risk of bias was assessed using JBI, RoB 2.0, and ROBINS-E tools, and Stata/SE 18.0 was used for meta-analysis. Meta-regression was used to examine the effects of therapy duration and mean age on dental manifestations' prevalence. The study receiv

SUBMITTER: Allam A 

PROVIDER: S-EPMC11854695 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature