Impact of HPV Types and Dendritic Cells on Recurrent Respiratory Papillomatosis' Aggressiveness.

ABSTRACT:

Objective

This study assesses the associations between dendritic cells, HPV 6 and 11, and Recurrent Respiratory Papillomatosis (RRP) aggressiveness.

Methods

The Derkay score was calculated using information obtained from the medical records. Biopsies from 36 patients with juvenile RRP (JRRP) and 43 adult RRP (ARRP) patients were analyzed under light microscopy, and their clinical data were collected. Immunohistochemical analysis using antibodies against CD83, CD1a, Factor XIIIa, and S100 was performed, and inflammatory cells were quantified. Data obtained were analyzed using the chi-squared test, in addition to the Mann-Whitney and Z tests for two proportions, considering a confidence interval of 95% and p < 0.05 as statistically significant.

Results

A higher q

SUBMITTER: Fernandes EE 

PROVIDER: S-EPMC11854725 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature