CD34+ Hematopoietic Stem Cell Counts in Alzheimer's Disease: A Meta-Analysis.

ABSTRACT:

Purpose

To assess the presence and quantity of CD34+ hematopoietic stem cells in patients with Alzheimer's disease (AD) through a meta-analysis.

Methods

A systematic search of the databases identified the observational and interventional studies reporting baseline CD34+ cell counts in AD patients. The data on mean counts and the measures of variation were extracted. Standardized mean differences (SMDs) were calculated using common and random effects models to compare the CD34+ cell counts between the AD patients and controls. Heterogeneity among the studies was evaluated using tau², tau, and I² statistics. The risk of bias was assessed using the Newcastle-Ottawa Scale and the ROBINS-I tool.

Patients

Five studies were included, comprising four obs

SUBMITTER: Suresh V 

PROVIDER: S-EPMC11854744 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature