Longitudinal assessment of white matter alterations in progressive supranuclear palsy variants using diffusion tractography.

ABSTRACT:

Introduction

White matter (WM) tract degeneration is a characteristic feature of progressive supranuclear palsy (PSP), with longitudinal changes observed in PSP-Richardson's syndrome (PSP-RS). Little, however, is known about the other PSP variants. We assessed cross-sectional and longitudinal WM degeneration across PSP variants using diffusion tractography.

Methods

Forty-eight PSP patients were recruited by the Neurodegenerative Research Group, Mayo Clinic, and underwent two diffusion MRI, 1-year apart. We measured fractional anisotropy and mean diffusivity from eight WM tracts reconstructed using deterministic tractography. Baseline and rates of change were compared across PSP variants grouped into PSP-RS, PSP-cortical, and PSP-subcortical, and correlated with clinical dise

SUBMITTER: Costa F 

PROVIDER: S-EPMC11854829 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature