Polyproline-Polyornithine Diblock Copolymers with Inherent Mitochondria Tropism.

ABSTRACT: Mitochondria play critical roles in regulating cell fate, with dysfunction correlating with the development of multiple diseases, emphasizing the need for engineered nanomedicines that cross biological barriers. Said nanomedicines often target fluctuating mitochondrial properties and/or present inefficient/insufficient cytosolic delivery (resulting in poor overall activity), while many require complex synthetic procedures involving targeting residues (hindering clinical translation). The synthesis/characterization of polypeptide-based cell penetrating diblock copolymers of poly-L-ornithine (PLO) and polyproline (PLP) (PLO_n-PLP_m, n:m ratio 1:3) are described as mitochondria-targeting nanocarriers. Synthesis involves a simple two-step methodology based on N-carboxyanhyd

SUBMITTER: Pegoraro C 

PROVIDER: S-EPMC11854869 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature