Amidated and Aminated PMSSO-Hydrogels as a Promising Enzyme-Sensitive Vehicle for Antianemic Drugs.

ABSTRACT: In this study, we report the synthesis and characterization of aminated poly(methyl silsesquioxane)-based hydrogels ((AP/MS)SO-hydrogels) as potential enzyme-sensitive vehicles for antianemic drugs. The hydrogels were synthesized via sol-gel polymerization and functionalized with amine groups. Characterization techniques included Congo red assay, Brunauer-Emmett-Teller (BET) surface area analysis, scanning electron microscopy, elemental analysis, ¹³C NMR, ²⁹Si NMR, and ATR-FTIR spectroscopy and microscopy of hydrogels. The sorption of ferric chloride and ferrous D-gluconate, as well as complexes of ferrous D-gluconate with HPCD, was evaluated. Crosslinking of the gel with bifunctional agents was performed to create a new amide enzyme-sensitive bond, followed by infrar

SUBMITTER: Orlova P 

PROVIDER: S-EPMC11854879 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature