Association of rs3798220 Polymorphism with Cardiovascular Incidents in Individuals with Elevated Lp(a).

ABSTRACT: Background/Objectives: Lipoprotein (a) [Lp(a)] plays a significant role in atherosclerosis and cardiovascular disease (CVD). Genetic regulation of Lp(a) involves variations in the apo(a) LPA gene, as specific polymorphisms like rs10455872 and rs3798220, both linked to higher Lp(a) levels and CVD. CVD remains the leading global cause of death, with high Lp(a) levels increasingly recognized as a significant factor in younger patients with no other CVD risk factors. We aimed to evaluate the association of LPA genetic variations with Lp(a) levels and its effect on cardiovascular risk as there are existing inconsistent findings. Methods: This case-control study included 251 subjects with a median age of 52 years (interquartile range, IQR = 17) and elevated Lp(a) leve

SUBMITTER: Lemesic DL 

PROVIDER: S-EPMC11854902 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature