ZDHHC-Mediated S-Palmitoylation in Skin Health and Its Targeting as a Treatment Perspective.

ABSTRACT: S-acylation, which includes S-palmitoylation, is the only known reversible lipid-based post-translational protein modification. S-palmitoylation is mediated by palmitoyl acyltransferases (PATs), a family of 23 enzymes commonly referred to as zDHHCs, which catalyze the addition of palmitate to cysteine residues on specific target proteins. Aberrant S-palmitoylation events have been linked to the pathogenesis of multiple human diseases. While there have been advances in elucidating the molecular mechanisms underlying the pathogenesis of various skin conditions, there remain gaps in the knowledge, specifically with respect to the contribution of S-palmitoylation to the maintenance of skin barrier function. Towards this goal, we performed PubMed literature searches relevant to S-palmitoylation

SUBMITTER: Abdulrahman FA 

PROVIDER: S-EPMC11854935 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature