Bioinformatics Analysis of the Anti-Inflammatory Mechanism and Potential Therapeutic Efficacy of <i>Kezimuke granules</i> in Treating Urinary Tract Infections by Inhibiting NLRP3 Inflammasome Activation.

ABSTRACT: Kezimuke granules (KZMK), derived from traditional Kazakh folk medicine, exhibit a variety of pharmacological properties. Long-term clinical studies have demonstrated their efficacy in clearing heat, detoxifying, promoting qi circulation, and alleviating gonorrhea. However, their specific pharmacological effects on urinary tract infections remain unclear. This study employed UHPLC-MS/MS technology to identify the blood components of KZMK and integrated network pharmacology with bioinformatics analysis for molecular docking validation. The anti-inflammatory activity of KZMK was further evaluated using a rat model of LPS-induced cystitis. A total of 17 components in KZMK were identified as capable of entering the bloodstream. Predictive analysis revealed that its primary targets inclu

SUBMITTER: Baishan A 

PROVIDER: S-EPMC11854959 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature