Generalization of Classification of AlkB Family Alkane Monooxygenases from <i>Rhodococcus</i> (<i>sensu lato</i>) Group Based on Phylogenetic Analysis and Genomic Context Comparison.

ABSTRACT: Alkane-oxidizing bacteria play a crucial role in the global carbon cycle. Rhodococcus species are well-known hydrocarbon degraders, distinguished by the harboring of multiple homologs of AlkB family alkane monooxygenases. Although different types of rhodococcal AlkBs have been described, the overall picture of their diversity remains unclear, leaving gaps in the current classification. We conducted a phylogenetic analysis of all AlkBs identified in Rhodococcus (sensu lato) and examined the genomic context of the corresponding genes. The sequence clustering was well aligned with genomic neighborhoods, allowing both features to be used as criteria for proposing AlkB types that form distinct phylogenetic groups and have characteristic genomic contexts. Our approach allowe

SUBMITTER: Petrikov KV 

PROVIDER: S-EPMC11854999 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature