Preliminary Investigation Towards a Safety Tool for Swine Brucellosis Diagnosis by a Proteomic Approach Within the One-Health Framework.

ABSTRACT: Brucellosis is a zoonosis that affects domestic and wild animals, causing reproductive disorders and significant economic losses in livestock. Brucella melitensis, B. abortus, and B. suis are the main agents of brucellosis in livestock and humans, thereby their control and eradication are crucial. Serological tests based on identification of antibodies against Brucella smooth lipopolysaccharides (sLPS) in the serum of infected animals are traditionally used. This approach shows two main limits: (i) tests can give false positives due to the similarity of Brucella sLPS with the LPS of other Gram-negative bacteria; (ii) antigen production represents a possible risk of zoonoses. In this work, a proteomic approach, starting from B. melitensis Brucellerg

SUBMITTER: Sagona S 

PROVIDER: S-EPMC11855111 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature