Effective Dose Reduction of Emamectin Benzoate Through Inhibition of Bx-SDR3 in Pine Wood Nematode Management.

ABSTRACT: Pine wood nematodes (Bursaphelenchus xylophilus, PWNs) are a major threat to Pinus koraiensis in northeast China, and emamectin benzoate (EB) is commonly used for their control. Although high doses of EB can alleviate symptoms of pine wilt disease (PWD), they do not fully eradicate PWNs due to their detoxification mechanisms. This study investigates the content of EB in P. koraiensis and its efficacy in controlling PWNs after exogenous application of EB. We found that while EB significantly reduced PWN populations, it did not eliminate them. Transcriptomic analysis of PWNs treated with concentration at 20% (LC₂₀) revealed that PWNs exhibit detoxification responses to low EB concentrations (LC₂₀), driven by the Bx-SDR3 gene. RNA interference

SUBMITTER: Zhuang Y 

PROVIDER: S-EPMC11855115 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature