Facile Synthesis of Pyridyl Rosamines as Potential Photosensitizers.

ABSTRACT: Rosamines represent one of the most promising groups of xanthene dyes. Their excellent photophysical properties allow their widespread application. Their use as photosensitizers in photodynamic therapy has recently gained considerable attention. Here, we report the facile, effective, microwave-assisted synthesis of rosamine dyes. Pyridylbenzaldehyde derivatives were reacted with 1,3-dialkylaminophenols or 8-hydroxyjulolidine in toluene without any additive. The resulting pyridyl rosamines were investigated for their cytotoxic effect against the A431 human epidermoid carcinoma cell line to estimate their potential as photosensitizers. The compounds displayed light-induced toxicity in the submicromolar or occasionally in the low nanomolar range. One of the julolidine-based derivatives exhibi

SUBMITTER: Bakos E 

PROVIDER: S-EPMC11855136 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature