Unveiling Racial Disparities in Localized Prostate Cancer: A Systems-Level Exploration of the lncRNA Landscape.

ABSTRACT:

Background/objectives

Prostate cancer (PC) is the most common non-cutaneous cancer in men globally, and one which displays significant racial disparities. Men of African descent (AF) are more likely to develop PC and face higher mortality compared to men of European descent (EU). The biological mechanisms underlying these differences remain unclear. Long non-coding RNAs (lncRNAs), recognized as key regulators of gene expression and immune processes, have emerged as potential contributors to these disparities. This study aimed to investigate the regulatory role of lncRNAs in localized PC in AF men relative to those of EU and assess their involvement in immune response and inflammation.

Methods

A systems biology approach was employed to analyze differentially expressed (DE) ln

SUBMITTER: Morgan RA 

PROVIDER: S-EPMC11855151 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature