Unravelling the Relationship Between Height, Lean Mass, Alzheimer's Disease and Cognition Through Mendelian Randomization.

ABSTRACT:

Background

Genetic evidence from Mendelian randomization (MR) analyses suggests that higher lean mass causally protects against Alzheimer's disease (AD) and enhances cognitive function. However, the potential confounding role of height, which shares genetic etiology with lean mass, has not been fully examined.

Methods

Genetic predictors of whole-body lean mass were obtained from a genome-wide association study (GWAS) performed in the UK Biobank cohort (UKB; n = 448,322). Genetic predictors of height were also obtained from UKB (height_0.5M = 455,332) and from a GWAS meta-analysis (height_1.5Mn = 1,578,425). The study outcomes included clinically diagnosed AD (21,982 cases and 41,944 controls) and cognitive performance (n = 269,867). A

SUBMITTER: Huang J 

PROVIDER: S-EPMC11855215 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature