The Association of Genetic Variants Within the Type XII Collagen and Tenascin C Genes with Knee Joint Laxity Measurements.

ABSTRACT:

Background/objectives

Types I, V, and XI collagen gene variants have been reported to associate with measurements of knee joint laxity and/or absolute knee ligament length changes. Type XII collagen and tenascin C are also ligament structural proteins whose expression is regulated by mechanical loading. This study investigated whether COL12A1 and TNC variants are associated with knee laxity and/or ligament length changes.

Methods

Genu recurvatum, anterior-posterior tibial translation, external-internal tibial rotation, and ligament length changes were measured in 128 healthy participants. They were genotyped for COL12A1 (rs970547) and TNC (rs1061494, rs2104772, rs1138545).

Results

Both the COL12A1 AA and TNC rs1061494 TT genot

SUBMITTER: Beckley S 

PROVIDER: S-EPMC11855217 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature