Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs.

ABSTRACT:

Background

EMSY could be involved in low-level susceptibility to breast and ovarian cancer. Gene amplification is seen in a proportion of breast and ovarian tumours and correlates with poor prognosis in breast cancer patients. Furthermore, the EMSY protein silences a transcription activation domain in BRCA2 exon 3.

Methods

We used a genetic association study design to determine if common genetic variation (frequency > or = 5%) in EMSY was associated with breast or ovarian cancer risk in the British population. Haplotype tagging single-nucleotide polymorphisms (htSNPs) were selected from the HapMap database and genotyped using Taqman in two large study sets of white British women (n [breast set] = 2343 cases and 2284 controls, n [ovarian set] = 864 cases and 864 controls). Ha

SUBMITTER: Benusiglio PR 

PROVIDER: S-EPMC1185523 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature