Upgrade of Weak σ-Hole Bond Donors via Cr(CO)₃ Complexation.

ABSTRACT: Molecular recognition mediated by σ-hole interactions is enhanced as the electrostatic potential at the σ-hole becomes increasingly positive. Traditional methods to strengthen σ-hole donor ability of atoms such as halogens often involve covalent modifications, such as, introducing electron-withdrawing substituents (neutral or positively charged) or electrochemical oxidation. Metal coordination, a relatively underexplored approach, offers a promising alternative. In this study, η⁶-coordination of Cr(CO)₃ to haloarenes, a neutral system, is demonstrated to significantly increase the electrophilic character of halogen bond donors, enabling weak donors such as chloroanisole to form short and directional Cl⋅⋅⋅O halogen bonds. Structural characterization using single-crysta

SUBMITTER: Dhaka A 

PROVIDER: S-EPMC11855244 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature