Antimicrobial Polymers at the Membrane Interface: Impact of Macromolecular Architecture.

ABSTRACT: Antimicrobial resistance (AMR) is a major cause of death worldwide. This urges the search for alternatives to antibiotics, and antimicrobial polymers hold promise due to their reduced susceptibility to AMR. The topology of such macromolecules has a strong impact on their activity, with bottlebrush architectures outperforming their linear counterparts significantly. Consequently, understanding the specific behavior of macromolecules featuring a confined conformation of linear subunits is pertinent. This study focusses on revealing fundamental differences between architectures regarding properties as well as interaction with biological membranes. Various analytical techniques (using membrane mimics and spectroscopic methods) are used to generate insights revealing the following trends: A) Th

SUBMITTER: Bapolisi AM 

PROVIDER: S-EPMC11855246 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature