NMFProfiler: a multi-omics integration method for samples stratified in groups.

ABSTRACT:

Motivation

The development of high-throughput sequencing enabled the massive production of "omics" data for various applications in biology. By analyzing simultaneously paired datasets collected on the same samples, integrative statistical approaches allow researchers to get a global picture of such systems and to highlight existing relationships between various molecular types and levels. Here, we introduce NMFProfiler, an integrative supervised NMF that accounts for the stratification of samples into groups of biological interest.

Results

NMFProfiler was shown to successfully extract signatures characterizing groups with performances comparable to or better than state-of-the-art approaches. In particular, NMFProfiler was used in a clinical study on atopic dermatitis (AD) a

SUBMITTER: Mercadie A 

PROVIDER: S-EPMC11855281 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature