Differentially Expressed Genes in Cardiomyocytes of the First Camelized Mouse Model, Nrap^c.255ins78 Mouse.

ABSTRACT: Background/Objectives: The first camelized mouse model (Nrap^c.255ins78) was developed to investigate the mechanisms underlying camels' adaptation to extreme environments. Previous studies demonstrated that these mice exhibit a cold-resistant phenotype, characterized by increased expression of inflammatory cytokine-related genes in the heart under cold stress. Nebulin-related anchoring protein (NRAP) plays a critical role in organizing myofibrils during cardiomyocyte development. This study builds on prior research by analyzing the heart transcriptomes of Nrap^c.255ins78 mice under non-stress conditions to explore the origins of inflammatory cytokine responses during cold exposure. Methods: RNA sequencing was performed on the hearts of

SUBMITTER: Lee SY 

PROVIDER: S-EPMC11855364 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature