Pharmacogenetics in Response to Biological Agents in Inflammatory Bowel Disease: A Systematic Review.

ABSTRACT: Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders influenced by microbial, environmental, genetic, and immune factors. The introduction of biological agents has transformed IBD therapy, improving symptoms, reducing complications, and enhancing patients' quality of life. However, approximately 30% of patients exhibit primary non-response, and 50% experience a loss of response over time. Genetic and non-genetic factors contribute to variability in treatment outcomes. This systematic review aims to thoroughly analyze and assess existing studies exploring the relationships between genetic variations and individual responses to biologic drugs, in order to identify genetic markers that are predictive of treatment efficacy, risk of adverse effects, or drug toxicity, thereby in

SUBMITTER: Ballesta-Lopez O 

PROVIDER: S-EPMC11855474 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature