Bioactivity Assessment of Functionalized TiO₂ Powder with Dihydroquercetin.

ABSTRACT: Biological activities, including cell viability, oxidative stress, genotoxicity/antigenotoxicity, and antimicrobial activity, were evaluated for a visible-light-responsive TiO₂-based ICT complex with dihydroquercetin (DHQ) and compared with pristine TiO₂, its inorganic component. Pristine TiO₂ did not induce cytotoxicity in MRC-5 or HeLa cells within the tested concentration range (1-20 mg/mL), while TiO₂/DHQ displayed a significant reduction in cell viability in both cell lines at higher concentrations (≥10 mg/mL). The analysis of reactive oxygen species (ROS) production revealed that TiO₂/DHQ significantly reduced ROS levels in both cell types (MRC-5 and HeLa), with HeLa cells showing a more substantial reduction at lower concentrati

SUBMITTER: Niksic V 

PROVIDER: S-EPMC11855565 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature