In Vitro Assessment of Bacillus thuringiensis Exopolysaccharides and Their Effects on Gut Microbiota from Ulcerative Colitis In Vitro.

ABSTRACT: Bacillus thuringiensis exopolysaccharide BPS-2 inhibits malondialdehyde secretion, enhances antioxidant enzyme activities, and significantly improves the antioxidant status of inflammatory cells. In the present study, the apparent morphology and spatial conformation of BPS-2 were analyzed further, and several functional properties were investigated. The results demonstrated that BPS-2 was a polymeric straight-chain polysaccharide with good thermal stability, exhibiting non-Newtonian properties and good antioxidant and anticancer activities. Notably, this study systematically investigated the impact of BPS-2 on the intestinal microbiota composition in patients diagnosed with ulcerative colitis. Through in vitro fermentation of fecal bacteria collected from six volunteers, it was foun

SUBMITTER: Gao Z 

PROVIDER: S-EPMC11855630 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature