Differential Expression of tRNA-Derived Small RNA Markers of Antidepressant Response and Functional Forecast of Duloxetine in MDD Patients.

ABSTRACT:

Background/objectives

Duloxetine, despite being a leading treatment option for major depressive disorder (MDD), exhibits a relatively low adequate response rate when used as a monotherapy, and the fundamental molecular mechanisms remain largely elusive. tRNA-derived small RNA (tsRNA) is a particularly interesting and new class of molecules that is becoming increasingly noticeable for investigation.

Methods

We integrated small RNA sequencing with bioinformatics approaches to dissect the expression profiles of tsRNAs and decipher their functional roles post-duloxetine treatment. Subsequently, molecular docking experiments were carried out to validate the potential functions.

Results

Ten tsRNAs significantly changed in the duloxetine response group after an 8-week therap

SUBMITTER: Wang X 

PROVIDER: S-EPMC11855652 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature