From Local to Systemic: The Journey of Tick Bite Biomarkers in Australian Patients.

ABSTRACT: Tick bites and tick-related diseases are on the rise. Diagnostic tests that identify well-characterised tick-borne pathogens (TBPs) possess limited capacity to address the causation of symptoms associated with poorly characterised tick-related illnesses, such as debilitating symptom complexes attributed to ticks (DSCATT) in Australia. Identification of local signals in tick-bitten skin that can be detected systemically in blood would have both clinical (diagnostic or prognostic) and research (mechanistic insight) utility, as a blood sample is more readily obtainable than tissue biopsies. We hypothesised that blood samples may reveal signals which reflect relevant local (tissue) events and that the time course of these signals may align with local pathophysiology. As a first step towards te

SUBMITTER: Lee W 

PROVIDER: S-EPMC11855657 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature