The Retinoic-Acid-Related Orphan Receptor Alpha May Be Highly Involved in the Regulation of Seasonal Hair Molting.

ABSTRACT: Seasonal molting in mammals is a crucial survival strategy, yet the underlying molecular mechanisms have not been fully characterized. Melatonin, serving as a bridge for the transmission of photoperiod signals, plays a significant regulatory role in animals' seasonal molting, and the physiological regulatory effects of melatonin signaling are highly dependent on the retinoic-acid-related orphan receptor alpha (Rorα). Hair follicle stem cells (HFSCs) are the most essential cell type in the process of hair follicle regeneration and seasonal replacement. Therefore, this study aims to discuss the regulatory effects of melatonin and its nuclear receptor RORA on HFSCs. This research found that RORA can downregulate cellular proliferation levels by inhibiting the cell cycle of HFSCs, while

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11855665 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature