Circulating RNA Markers Associated with Adenoma-Carcinoma Sequence in Colorectal Cancer.

ABSTRACT: Colorectal cancer progresses through a well-defined adenoma-carcinoma sequence (ACS), which is pivotal for early detection and intervention. While ACS-based surveillance has been instrumental, its reliance on tissue sampling limits accurate staging. Liquid biopsies, including circulating tumor DNA (ctDNA) and extracellular RNA, have emerged as non-invasive alternatives, yet they primarily detect genetic alterations or passive RNA release rather than active biological processes. Thus, there is a need for biomarkers that reflect real-time immune responses and tumor-microenvironment interactions during ACS progression. This study aimed to identify circulating RNA biomarkers associated with ACS by analyzing blood samples from 160 individuals across five groups: colorectal cancer, advanced aden

SUBMITTER: Kim LA 

PROVIDER: S-EPMC11855670 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature