Metabolomics, Genetics, and Environmental Factors: Intersecting Paths in Abdominal Aortic Aneurysm.

ABSTRACT: Abdominal aortic aneurysm represents a significant public health concern, particularly in men aged 55 to 64, where it occurs in about 1%. We investigated the metabolomics and genetics of AAA by analyzing a cohort including 76 patients with AAA and randomly selected 228 controls. Utilizing the Metabolon DiscoveryHD4 platform for non-targeted metabolomics profiling, we identified several novel metabolites significantly associated with AAA. These metabolites were primarily related to environmental and lifestyle factors, notably smoking and pesticide exposure, which underscores the influence of external factors on the progression of AAA. Additionally, several genetic variants were associated with xenobiotics, highlighting a genetic predisposition that may exacerbate the effects of these enviro

SUBMITTER: Fernandes Silva L 

PROVIDER: S-EPMC11855682 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature