Long-Term Exposure to Lambda-Cyhalothrin Reveals Novel Genes Potentially Involved in Aedes aegypti Insecticide Resistance.

ABSTRACT: Insecticide resistance in Aedes aegypti populations hinders vector control programs. Many studies have focused on the classical mechanisms, kdr mutations, and metabolic enzymes to understand the development of insecticide resistance. In this study, we subjected a strain of Ae. aegypti to selective pressure for 13 consecutive generations to understand the development and extent of insecticide resistance. We delved into the transcriptomics of this pressured strain to gain insights into the molecular changes underlying insecticide resistance in Ae. aegypti. Our data suggest mosquito resistance is influenced by additional mechanisms that are difficult to explain using only classical mechanisms. The response by mosquitoes varies depending on the exposure time. Initia

SUBMITTER: Mejia A 

PROVIDER: S-EPMC11855735 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature