Combined Effect of Conventional Chemotherapy with Epigenetic Modulators on Glioblastoma.

ABSTRACT:

Background/objectives

Glioblastoma is the most common malignant primary brain tumor, characterized by necrosis, uncontrolled proliferation, infiltration, angiogenesis, apoptosis resistance, and genomic instability. Epigenetic modifiers hold promise as adjuvant therapies for gliomas, with synergistic combinations being explored to enhance efficacy and reduce toxicity. This study aimed to evaluate the effects of single or combined treatments with various anticancer drugs (Carboplatin, Paclitaxel, Avastin), natural compounds (Quercetin), and epigenetic modulators (suberoylanilide hydroxamic acid and 5-Azacytidine) on the expression of some long noncoding RNAs and methylation drivers or some functional features in the U87-MG cell line.

Methods

Treated and untreated U87-MG cells

SUBMITTER: Albulescu A 

PROVIDER: S-EPMC11855767 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature