Correlations Between Amelioration of Rotenone-Induced Parkinson's Symptoms by <i>Amomum tsaoko</i> Flavonoids and Gut Microbiota in Mice.

ABSTRACT: Parkinson's disease (PD) is the second most common neurodegenerative disease, but the existing therapeutic drugs for PD have limitations; thus, there is an urgent need to discover new methods of prevention and treatment. Amomum tsaoko Crevost et Lemarie (AT) is a classic traditional Chinese medicine and food. Its main pharmacological effect is the regulation of the gastrointestinal tract. To date, no studies on the use of AT or its extracts to treat PD have been reported. In this study, a rotenone-induced PD mouse model was utilized to evaluate the protective effect of Amomum tsaoko flavonoids (ATFs) and to elucidate the role of the gut microbiota in this effect. The results demonstrated that ATFs not only ameliorated the motor and constipation symptoms but also reduced the l

SUBMITTER: Liu L 

PROVIDER: S-EPMC11855768 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature