Properties of "Stable" Mosquito Cytochrome P450 Enzymes.

ABSTRACT: The use of insecticides is widespread in the control of debilitating mosquito-borne diseases. P450 enzymes (CYPs) play essential roles in mosquito physiological function but also in the enzymatic detoxification of xenobiotics. Broadly speaking, CYPs can be classified as "stable", meaning those that have no or very few paralogs, and "labile", constituting gene families with many paralogous members. The evolutionary dichotomy between "stable" and "labile" P450 genes is fuzzy and there is not a clear phylogenetic demarcation between P450s involved in detoxification and P450s involved in essential metabolic processes. In this study, bioinformatic methods were used to explore differences in the sequences of "stable" and "labile" P450s that may facilitate their functional classification. Genomic

SUBMITTER: Tzotzos G 

PROVIDER: S-EPMC11855896 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature