Translating Biomarker Research into Clinical Practice in Orthopaedic Trauma: A Systematic Review.

ABSTRACT: Background/Objectives: Orthopaedic trauma management in polytrauma patients presents challenges, particularly in selecting between damage control orthopaedics (DCO) and early appropriate care (EAC). This systematic review evaluates these approaches and explores the role of biomarkers in optimising surgical timing. The primary objective of this review was to evaluate the potential clinical utility of biomarkers in guiding surgical timing and predicting perioperative complications. The secondary objective was to compare the effectiveness of DCO and EAC approaches, focusing on their impact on patient outcomes when controlled for Injury Severity Scores (ISSs). Methods: A systematic search of PubMed, MEDLINE, and Google Scholar identified studies focusing on fracture management (D

SUBMITTER: Baur A 

PROVIDER: S-EPMC11856232 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature