Capsicum chinense Jacq. fruit plays an immunomodulatory role in cytokine attenuation and DNA damage protection.

ABSTRACT: Capsicum chinense (C. chinense) Jacq., recognized for its bioactive compounds, has attracted interest due to its possible immunomodulatory and DNA-damage-protective effects. This study aimed to assess the immunomodulatory, anti-inflammatory, and DNA protection abilities of organic extracts (methanol, ethyl acetate, and petroleum ether) from C. chinense. The immunomodulatory effects were evaluated in Long Evans rats induced with SRBC. At the same time, the anti-inflammatory potential was investigated in LPS-stimulated RAW264.7 macrophages by quantifying pro-inflammatory mediators such as COX-2, iNOS, TNF-α, IL-β, and IL-6. Protective activity against DNA damage was assessed using a method that induces damage with a Fenton reagent. Cytotoxicity was tested on the Hela cell line to gauge the c

SUBMITTER: Saha S 

PROVIDER: S-EPMC11856283 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature