Acute and sub-acute toxicity of ethanol extracts of Hagenia abyssinica and Rumex abyssinicus flowers in Swiss albino mice.

ABSTRACT:

Background

Hagenia abyssinica (Bruce) J.F. Gmel (Family: Rosaceae) and Rumex abyssinicus Jacq (Family: Polygonaceae) are valuable medicinal plants traditionally used in Ethiopia to treat various diseases. Recent studies have also demonstrated that solvent extracts of these plants exhibit molluscicidal activities under laboratory conditions, highlighting their potential for snail control. However, limited information is available regarding their safety profiles.

Objective

This study aimed to evaluate acute, and sub-acute toxicity of 70% ethanol extracts of H. abyssinica and R. abyssinicus flowers in Swiss albino mice, following the Organization for Economic Co-operation and Development guidelines 423 and 407.

Methods

In the acute toxicity study, both extracts were admi

SUBMITTER: Gemeda HB 

PROVIDER: S-EPMC11856396 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature