Plasma attenuates endothelial injury compared to crystalloids in a ventilated rat pneumosepsis model.

ABSTRACT:

Background

The dysregulated immune response during sepsis involves endothelial injury, which may be augmented by infusion of clear fluids such as crystalloids. Plasma has been suggested as an alternative resuscitation fluid but it is unclear whether previously observed benefits were due to the type of fluid, or due to less volume required to restore tissue perfusion. We hypothesized that resuscitation with plasma reduces endothelial injury, inflammation, and organ injury compared to similar and higher volumes of crystalloids in a rat pneumosepsis model.

Methods

Rats were intratracheally inoculated with Streptococcus Pneumoniae to induce pneumosepsis. Twenty-four hours after inoculation, animals were randomized to 4 groups: healthy controls (non-resuscitated, n = 6), 10 ml/kg

SUBMITTER: van den Brink DP 

PROVIDER: S-EPMC11856581 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature