Clock Proteins Have the Potential to Improve Term Delivery Date Prediction: A Proof-of-Concept Study.

ABSTRACT: Our ability to accurately predict the delivery date of term pregnancies is limited by shortcomings of modern-day clinical tools and due date estimation methods. The pregnancy clock is a series of coordinated and harmonized signals between mother, fetus, and placenta that regulate the length of gestation. Clock proteins are thought to be important mediators of these signals, yet few studies have investigated their potential utility as predictors of term delivery date. In this study, we performed a cross-sectional proteome analysis of 2648 serum samples collected between 18 and 28 weeks of gestation from mothers who delivered at term. The cohort included pregnancies both with and without complications. A total of 15 proteins of diverse functionalities were shown to have a direct association

SUBMITTER: Dufford MT 

PROVIDER: S-EPMC11856609 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature