Different Long-Term Nutritional Regimens of Drosophila melanogaster Shape Its Microbiota and Associated Metabolic Activity in a Sex-Specific Manner.

ABSTRACT: The dietary habits of fruit flies profoundly influence their fitness, morphology, and physiology yet the mechanisms underlying these effects remain incompletely understood. To address this gap, the relationship between dietary regimens and the composition and function of adult Drosophila melanogaster microbiota was investigated in the present study. The adult fly microbiota communities that were reared for long time on five different diets were characterized by means of 16S rRNA sequencing. Obtained results revealed distinct community structures associated with each dietary regimen, which was additionally corroborated through machine learning-based analysis. In general, sugar-rich diets correlate with microbial ecosystems of higher richness/diversity. Dominance of the phyla Prote

SUBMITTER: Jelena R 

PROVIDER: S-EPMC11856610 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature