Mutational and co-mutational landscape of early onset colorectal cancer.

ABSTRACT:

Introduction

Colorectal cancer (CRC) incidence and mortality before 50 have been rising alarmingly in the recent decades.

Methods

Using a cohort of 10,000 patients, this study investigates the clinical, mutational, and co-mutational features of CRC in early-onset (EOCRC, < 50 years) compared to late-onset (LOCRC, ≥ 50 years).

Results

EOCRC was associated with a higher prevalence of Asian and Hispanic patients, rectal or left-sided tumors (72% vs. 59%), and advanced-stage disease. Molecular analyses revealed differences in mutation patterns, with EOCRC having higher frequencies of TP53 (74% vs. 68%, p < 0.01) and SMAD4 (17% vs. 14%, p = 0.015), while BRAF (5% vs. 11%, p < 0.001) and NOTCH1 (2.7% vs. 4.1%, p = 0.01

SUBMITTER: Alshenaifi JY 

PROVIDER: S-EPMC11856746 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature