Overall Survival Following Interval Complete Gross Resection of Advanced Ovarian Cancer via Laparoscopy Versus Open Surgery: An Analysis of the National Cancer Database.

ABSTRACT: Background: Advanced epithelial ovarian cancer (EOC) has traditionally been treated with primary debulking surgery; however, recent phase III trials have demonstrated similar survival outcomes for patients who were randomized to neoadjuvant chemotherapy followed by interval debulking (IDS) when compared to patients who underwent PDS. Methods: We sought to evaluate a cohort of patients with EOC diagnosed between 2010 and 2019 who underwent complete cytoreduction (R0-no gross residual disease) during IDS. We compared the outcomes after R0 resection via MIS versus laparotomy in IDS. The primary endpoint was overall survival (OS). Kaplan-Meier analysis and inverse probability of treatment weighting (IPTW) were used. Cases were stratified by surgical extent and within the MIS coho

SUBMITTER: Hayek J 

PROVIDER: S-EPMC11856761 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature