Retinal and Choroidal Alterations in Thyroid-Associated Ophthalmopathy: A Systematic Review.

ABSTRACT: Thyroid-associated ophthalmopathy (TAO), or Graves' orbitopathy (GO), is a complex autoimmune disorder affecting orbital tissues, often leading to vision-threatening complications such as dysthyroid optic neuropathy (DON). In this systematic review, conducted following PRISMA guidelines, 22 studies were evaluated to investigate the role of optical coherence tomography (OCT) in assessing retinal and choroidal changes in TAO. Parameters such as the retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), ganglion cell layer (GCL), and choroidal thickness were analyzed. RNFL changes varied by disease severity, with significant thinning in DON due to nerve fiber loss and thickening in early DON due to optic disk edema. Subfoveal choroidal thickness (SFCT) was consistently higher in activ

SUBMITTER: Ioana AM 

PROVIDER: S-EPMC11856781 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature