Investigating casual association among gut microbiome and esophageal cancer: A Mendelian randomization study.

ABSTRACT: The gut microbiota has been strongly linked to gastrointestinal cancer, but the relationship between gut microbiota and esophageal cancer (EC) is still not fully understood. We conducted a 2-sample Mendelian randomization (MR) study to unveil the potential impact of intestinal microorganisms on EC in East Asian populations. In order to delve deeper into the potential causal relationship between gut microbiota and EC, we conducted a 2-sample MR analysis, utilizing 211 single nucleotide polymorphisms associated with gut microbiota, sourced from the largest genome-wide association study on gut microbiota, for our analysis. To estimate the causal relationship, we employed the inverse variance weighting method. In addition, to assess the potential influence of pleiotropy, we used MR-Egger regre

SUBMITTER: Atabieke F 

PROVIDER: S-EPMC11856886 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature