Job involvement in heavy manual or physical work associated with epigenetic age: A Mendelian randomization study.

ABSTRACT: Engaging in heavy manual or physical work has been linked to various health outcomes, but its effect on physiological aging, as measured by epigenetic clocks, remains unclear. This study aims to analyze the causal relationship between heavy manual or physical work and epigenetic age acceleration using Mendelian randomization (MR). In this study, we explored the causal link between job involvement in heavy manual or physical work and epigenetic age acceleration measured by 4 different epigenetic clocks using 2-sample MR. Our analytical approach included inverse-variance weighting (IVW), MR-Egger, weighted median, and weighted mode methods. The primary analyses utilized IVW with random effects, supplemented by sensitivity and heterogeneity tests using both IVW and MR-Egger. MR-Egger was also

SUBMITTER: Sun X 

PROVIDER: S-EPMC11856914 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature