Exploring the causal associations of gout and serum uric acid levels on erectile dysfunction: A Mendelian randomization study.

ABSTRACT: Several observational studies have suggested a possible link between gout, serum uric acid (UA) levels, and erectile dysfunction (ED). Nonetheless, the current body of evidence does not allow for a conclusive determination regarding the influence of gout and serum UA on the likelihood of developing ED. The primary aim of this research was to explore the potential causal relationship between gout and serum UA levels in relation to ED utilizing Mendelian randomization (MR) analysis. The principal analytical method employed was inverse variance weighting (IVW). Following this, a sensitivity analysis was performed using Cochran Q-test, funnel plots, MR-Egger regression, and the leave-one-out method. The findings from the IVW analysis revealed no significant association between gout and ED (odd

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11856936 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature